Ignacio Prego is considered by the specialist press to be one of the leading harpsichordists of his generation. First Prize winner at the 2012 Westfield International Harpsichord Competition, he has performed in major cities in the United States, Canada, Asia, South America, and Europe. He has played at venues such as the Alice Tully Hall at the Lincoln Centre in New York, the Benaroya Hall in Seattle, the National Centre for the Performing Arts in Beijing, the Teatros del Canal and National Auditorium in Madrid, and at the Berkeley, Boston, Seville (FeMAS), Vancouver, Utrecht and Aranjuez festivals.

Prego regularly collaborates with musicians such as Monica Huggett, Nic McGegan, Harry Bicket, Hiro Kurosaki and Maurice Steger. He has also performed as a soloist with The English Concert in New York and the Portland Baroque Orchestra in the Oregon Bach Festival. Recently he appeared with the Navarra Symphony Orchestra at the Palacio Euskalduna in Bilbao as part of the Musika-Música festival. He made his conducting debut with this orchestra in 2022, and has worked with jazz and flamenco artists, such as Moisés P. Sánchez, with whom he premiered the two-man show A Night With John Dee at the Teatro Conde Duque, and National Flamenco Award winning dancer Marcos Flores.

Following the success of his album The Complete French Suites by JS Bach, Prego released The Goldberg Variations in 2016, becoming the first Spanish harpsichordist to record a solo album for the prestigious Glossa label. He released his fourth album dedicated to Johann Sebastian Bach, Partitas & English Suite, in June 2022. It was presented in concert during the 22/23 season at the Utrecht Early Music Festival, the National Gallery in Washington DC, and music festivals in San Francisco, Valencia, Zamora and Burgos. In addition to his concert career, during the 2014/2015 season he lectured at Yale University in the USA. He has also lectured at the Madrid Royal Conservatory and is a regular master class teacher at several American universities.