After working as a teacher for three years, Isabelle Ruf-Weber began her professional training in wind orchestra conducting in 1985 at the Lucerne University of Music, studies which she completed in 1989 with honors. In the same year, she got a flute teacher diploma.

She completed her musical education at the University of Michigan in orchestral conducting and with Sylvia Caduff in Lucerne in choral conducting. She also completed several master's degrees abroad and a postgraduate course in conducting with Johannes Schlaefli at the University of Arts in Zurich.

Isabelle Ruf-Weber is an open-minded artist with great versatility, which allows her to conduct very diverse orchestras. She conducted the FM Neuenkirch Wind Orchestra for 25 years, from 2000 to 2003 shee also took over the direction of the Sursee Orchestra and, later, from 2003 to 2007, the Malters Orchestra Association (Switzerland). She was artistic director of the Wind Orchestra of Baden-Württemberg for 12 years, until 2013, and music director of the Landwehr Wind Orchestra of Freiburg, until 2017.

She has been the titular director and production director of the Sursee Municipal Theatre (Switzerland) for 20 intense years, a successful task that ended last March 2022.

She collaborates with several youth orchestras, in particular with the National Youth Harmony and the Youth Music of South Tyrol, and with various orchestral projects as guest conductor and music pedagogue.

In the field of teaching, she works for the training and development of juries and conductors and is a visiting professor at the Bundesakademie in Trossingen (Germany). She also taught wind orchestra conducting at the Lucerne University of Music from 2009 to 2014.

In 2017 she received the Stephan Jaeggi Award in recognition of her commitment to Swiss wind music.