He began his violin studies in Córdoba, Argentina and in 1984, he went to live in Germany, where he studied at the Cologne University of Music (Hochschule für Musik Köln) with Professor Franzjosef Maier. In 1985, together with colleagues from University, he was cofounder of Concerto Köln Orchestra. In 1986, Reinhard Goebel invited Manfredo to join Musica Antiqua Köln, a group whose distinctive style became remarkably well-known in the field of baroque music. Within the next years, he travelled all around Europe, Asia, Oceania, North and South America, performing both as soloist and conductor and offering over one-hundred concerts a year. In late 1991, he began working as a freelance musician and was invited to play by the most renowned baroque music directors. In 1996, he created The Rare Fruits Council, an instrumental ensemble. Its recordings have ever since been both highly recognised and prized.

In year 2000, La Barroca del Suquía was founded in Córdoba, Argentina. With its characteristic original baroque instruments, it is now thought to be one of the best musical ensembles in Latin America, offering master pieces of the baroque repertoire in their original versions, never seen before in the American continent.

Since 1991, Manfredo got very closed to Jordi Savall by becoming the principal first violin player in Savall’s orchestra Le Concert des Nations and Hespèrion XXI group.